It’s advisable to place the barbs at the bottom of the radiator because this produces the lowest temps. You can achieve lower temps with the bars at the bottom because of convection with in the radiator. Convection is hot water rises and cold water sinks. If the outlet (water going to your water blocks) is at the bottom of the radiator you’re insuring the coolest water is leaving the radiator. If the outlets are at the top you have the warmer water rising to wards the outlet to sent back though your water blocks which is not advisable. As for removing the air from your radiator, it is a little easier when the barbs are at the top but not by much because no matter which way up you have the barbs you still have to push the air down ½ the radiator.